Introduction
UNIL is a leading international teaching and research institution, with over 5,000 employees and 17,000 students split between its Dorigny campus, CHUV and Epalinges. As an employer, UNIL encourages excellence, individual recognition and responsibility.
Presentation
A postdoctoral position, funded by the Swiss National Science Foundation, is available in the laboratory of Stephan Kellenberger at the Department of biomedical Sciences (DSB) of the University of Lausanne. Our laboratory works towards a molecular understanding of the activation mechanisms of the “acid-sensing ion channels”(ASICs). ASICs are neuronal ion channels involved in pain sensation, the expression of fear, and neurodegeneration after ischemia (for review see Kellenberger and Schild, Pharmacol Rev 67: 1-35, 2015).
Job information
Expected start date in position : December 2024 or January 2025
Contract length : 18 months
Activity rate : 100%
Workplace : Department of Biomedical Sciences Rue du Bugnon 27 1011 Lausanne
Your responsibilities
The postdoctoral fellow will investigate the ASIC activation mechanism with functional approaches, based on predictions from high-resolution structures and from Molecular Dynamics simulations. To this end, she/he will analyze Molecular Dynamics data and use electrophysiological and fluorescent approaches on mostly recombinantly expressed ASICs.
Your qualifications
We are looking for a talented and motivated postdoctoral researcher. Applicants need to have a PhD in life sciences or a related domain. They must have relevant experience with electrophysiology (patch-clamp, two-electrode voltage-clamp) and fluorescence approaches, and ideally be familiar with the analysis of protein structures. Additional desired qualifications are a basic knowledge of molecular biology and biochemistry.
What the position offers you
We are a small, dynamic and motivated team. The DSB, with 18 research teams, offers a stimulating and competitive research environment in modern biology with multidisciplinary expertise (www.unil.ch/dsb). Lausanne, with its university and the EPFL is a center of life science research.
Contact for further information
Prof. Stephan Kellenberger
Stephan.Kellenberger@unil.ch
Département des Sciences biomédicales
Rue du Bugnon 27 1011 Lausanne
Phone number : 0041 21 692 5422
Your application
Applications are invited in the form of a motivation letter, a curriculum vitae, a brief description of research experience and doctoral thesis, and the names and addresses of three academic references, before October 7, 2024.
Please, send your full application in Word or PDF.
Only applications through this website will be taken into account.
We thank you for your understanding.
Additional information
For further information, please consult the following publications that illustrate our approaches:
Roy S et al., 2022. Open Biol 12, 10.1098/rsob.220243
Vullo S et al., 2021. eLife 10, 10.7554/eLife.66488
