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In a groundbreaking study led by Prof. Fang Chen’s research group at the National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, a fascinating discovery was made. 

This team explored whether adding a special ingredient to the diets of weaned piglets could improve their growth and health outcomes. The ingredient? Dietary protease, an enzyme that breaks down proteins, making them easier to digest.

The researchers conducted an experiment with 90 piglets, divided into three groups. Each group was fed a different diet over a 28-day period. 

One group received a basic diet with composite enzymes but without protease (control group), another received a diet with no enzymes (negative control), and the last group received the same basic diet but with added protease.

The results were nothing short of remarkable. Piglets that received the protease-supplemented diet showed significantly improved growth performance. They gained more weight daily compared to their counterparts in the other groups. 

But the benefits didn’t stop at just weight gain. These piglets also exhibited enhanced antioxidant capacity, indicating a better ability to combat oxidative stress—a vital factor for overall health and disease resistance.

The study delved deeper to understand how protease was making such a positive impact. One of the critical findings was related to the piglets’ gut health. Piglets on the protease diet had healthier intestines. 

The protease helped in maintaining the integrity of the intestinal barrier, which is crucial for preventing harmful substances from entering the bloodstream.

Moreover, the protease-supplemented diet influenced the piglets’ immune responses. It reduced the levels of inflammatory markers and the expression of pro-inflammatory genes in the intestines. 

This means the piglets were not only growing better but were also experiencing less intestinal inflammation, which can be a significant stressor and growth inhibitor.

Another exciting discovery was the positive shift in the intestinal microbiota—the community of bacteria living in the gut. The protease diet increased the abundance of beneficial bacteria while reducing harmful ones. 

Beneficial bacteria like those from the Lachnospiraceae and Prevotellaceae families are known to aid in digestion and bolster immune health, creating a symbiotic environment where the piglets could thrive.

This study is more than just a win for piglets and their caretakers. It underscores the potential of dietary interventions in animal husbandry to promote better health and growth outcomes naturally. 

By harnessing the power of enzymes like protease, farmers can improve the welfare of their livestock, reduce reliance on antibiotics, and support sustainable farming practices.

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