The Martens Lab at the University of California, San Francisco (https://profiles.ucsf.edu/hanna.martens) is seeking postdoctoral researchers to lead projects focused on uncovering the fundamental mechanisms of physiological aging. The lab is particularly interested in investigating the key roles of tissue mechanics and innate immune signaling in shaping aging-related outcomes (Sladitschek-Martens et al., YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS–STING, Nature, 2022). By leveraging genetic mouse models, single-cell and spatial transcriptomics, imaging, mechanobiology assays, and flow cytometry, we explore how load-bearing structural cells contribute to maintaining youthful organ homeostasis and aim to identify the cellular and molecular mechanisms that drive the progressive breakdown of connective tissue mechanics with age.
Key Responsibilities:
- Lead an interdisciplinary research project integrating biophysics, immunology, and aging biology.
- Design and execute experiments using genetic mouse models, single-cell RNA sequencing, flow cytometry, imaging, histology, and data analysis.
- Ph.D. or M.D. degree.
- Strong publication record in peer-reviewed journals.
- Deep commitment to curiosity-driven scientific research.
Preferred Qualifications:
- Experience in immunology, mouse handling, and single-cell data analysis is preferred, but not required.
