PhD project in Beyond normal – Proteins in Alien Environments

Location: United Kingdom
Application Deadline: 10 February 2025
Published: 2 days ago

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Project details

What would happen if the liquid enabling life were not water, but a class of molecules with a similar melting range known as ‘ionic liquids’? Ionic liquids are, simply, liquids made of ions usually defined as having melting temperatures below 100C, for which there are millions of possible options. But the charges of these ions deliver quite different physico-chemical properties, and are able to modify the 3D-structure of proteins.

We seek a keen researcher willing to use a mixture of experimental and computational techniques to unravel the underlying principles behind protein structure in different ionic liquids, so that we can predictively redesign both the protein landscape and target new and renewably sourced ionic liquids for applications ranging from biosensors and 3D-printed materials to healthcare. And maybe just answer the question of what life might be like if it developed in these highly-charged environments …

As part of our team, you will develop new experimental high-throughput screening approaches, explore protein structure using computational methods including molecular dynamics, and apply machine-learning principles to solve this multi-variate puzzle. You will also have a range of opportunities to gain valuable transferrable skills (including through our doctoral college), network with international partners, and be well-set up for a role in either industry, data science or academia at the end of the programme.

94% of Loughborough’s research impact is rated world-leading or internationally excellent. REF 2021

Supervisors

Primary supervisor: Prof Anna Croft

Entry requirements

Our entry requirements are listed using standard UK undergraduate degree classifications i.e. first-class honours, upper second-class honours and lower second-class honours. To learn the equivalent for your country, please choose it from the drop-down below.

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Entry requirements for United Kingdom

Applicants should have at least, or expect to achieve, a 1st or good 2:1 MChem, MEng, or MSci or equivalent in an appropriate scientific discipline including chemistry, physics, computing, biology, or engineering, with a background in and passion for chemical sciences.

You will join a vibrant, inclusive, and supportive research team at Loughborough led by Prof Anna K Croft, with opportunities for collaboration with other internationally leading groups in academia and industry.

English language requirements

Applicants must meet the minimum English language requirements. Further details are available on the International website.

Fees and funding

Tuition fees for 2025-26 entry

UK fee

To be confirmed Full-time degree per annum

International fee

£28,600 Full-time degree per annum

Fees for the 2025-26 academic year apply to projects starting in October 2025.

Tuition fees cover the cost of your teaching, assessment and operating University facilities such as the library, IT equipment and other support services. University fees and charges can be paid in advance and there are several methods of payment, including online payments and payment by instalment. Fees are reviewed annually and are likely to increase to take into account inflationary pressures.

The successful candidate will also be required to pay bench fees of £4000.

How to apply

All applications should be made online. Under programme name, select ‘Chemical Engineering’. Please quote the advertised reference number: * AACME-24-050 * in your application.

To avoid delays in processing your application, please ensure that you submit the minimum supporting documents.

The following selection criteria will be used by academic schools to help them make a decision on your application. Whilst we do not expect a research proposal for this position, we will expect a personal statement.

Informal enquiries can be directed to Prof Anna Croft. Applications will be reviewed on a regular basis, with successful applicants expected to start as soon as possible. The post will be closed once filled.

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