Project details
Although plenty of cancer research is in the field of cancer cell biology, there is lack of knowledge that can cascade the biological theory to those measurable parameters that can be obtained non-destructive and in real-time at clinical level, i.e. via imaging. The ultimate diagnosis still rely purely on testing of biopsy.
Mechanical properties of tumour tissue can be used as indicators to predict the type cancer and their grade. The growth of tumour and its severity are determined by the capability of cells to multiply and migrate to the adjacent tissue.
Cell mechanics and their interaction with the local tissue structure play an important role in tumour growth and cancer cell invasion. In order to understand why different type of cancer cells respond differently to various chemical and physical treatments, it is critical to gain insight on the biophysical interactions between the invading cells and the local tissue structures.
Within this project we will focus on different type of breast cancers to investigate the interaction of tissue stiffness and cell mechanics at both tissue, cell and sub-celluar levels. In vitro 2D and 3D models will be established to replicate the tumour microenvironment and data derived from experimental work will further feed into modellings that can simulate the collective behaviours of cells in terms of tumour growth. The ultimate aim is to develop supplementary criteria based on the understanding of biophysical mechanisms in tumour growth and inform clinical decision.
94% of Loughborough’s research impact is rated world-leading or internationally excellent. REF 2021
Supervisors
Primary supervisor: Dr Yang Liu
Entry requirements
Our entry requirements are listed using standard UK undergraduate degree classifications i.e. first-class honours, upper second-class honours and lower second-class honours. To learn the equivalent for your country, please choose it from the drop-down below.
Entry requirements for United Kingdom
Applicants should have, or expect to achieve, at least a 2:1 Honours degree (or equivalent) in a related subject.
A relevant Master’s degree and / or experience in one or more of the following will be an advantage: Biophysics, Biotechnology, Nanotechnology, Mechanical Engineering, Materials, Biomedical Engineering.
English language requirements
Applicants must meet the minimum English language requirements. Further details are available on the International website.
Fees and funding
Tuition fees for 2024-25 entry
UK fee
£4,786 Full-time degree per annum
International fee
£27,500 Full-time degree per annum
2024-25 tuition fees are applicable to projects starting in October 2024, January 2025, April 2025 and July 2025.
Tuition fees cover the cost of your teaching, assessment and operating University facilities such as the library, IT equipment and other support services. University fees and charges can be paid in advance and there are several methods of payment, including online payments and payment by instalment. Fees are reviewed annually and are likely to increase to take into account inflationary pressures.
There is no funding aligned to this project. The successful applicant must be self-funded and able to cover funding for tuition fees and living expenses or have external sponsorship.
How to apply
All applications should be made online. Under programme name, select ‘Mechanical and Manufacturing Engineering/Electronic, Electrical & Systems Engineering’ and quote the advert reference number UF-YL-2024 in your application.
To avoid delays in processing your application, please ensure that you submit your CV and the minimum supporting documents.
The following selection criteria will be used by academic schools to help them make a decision on your application.
