Seeking a postdoctoral fellow to study the mechanisms whereby CD4+ T cells maintain graft-versus-host disease (GVHD) in tissues. This newly R01-funded project extends work recently published in Immunity (PMID: 36720219) and employs cutting-edge approaches to fate-map and inducibly delete genes of interest from T cells in mice with established GVHD. One focus will be on the transcription factors Tcf7 and TOX.
Approaches to be employed include single-cell RNA sequencing and ATACseq. Candidates will also gain experience in writing manuscripts and grants, along with oral presentations. A strong background in immunology and prior relevant mouse work is preferred. The University of Pittsburgh has strength in immunology, cancer immunology and systems immunology, making for a strong training environment.
Requirements are Doctorate in biology, preferably in immunology or in a sphere of work that created a strong immunology background
