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The research will be conducted in the group of Professor Volker Lauschke under the supervision of Ass. Prof. Shane Wright. In the group, we use 3D cell culture systems of primary human cells, microfluidics and integrative bioinformatics approaches to develop better model systems for prediction of drug toxicity and to identify novel therapeutic strategies for complex metabolic diseases, such as type 2 diabetes. In addition, we are interested in understanding the molecular basis of hepatic plasticity in liver injury and regeneration. Furthermore, we study the genetic basis of drug response and adverse drug reactions on a population-scale.
Your mission
The successful applicant will conduct screening of different pharmacological agents in 3D spheroid cultures of primary human liver cells of patients with fatty liver disease or healthy controls. Compound effects will be evaluated using a panel of biochemical and optical readouts.
Your profile
We are looking for a driven candidate who is excited about translational pharmacology and the identification of new therapeutic targets in metabolic diseases. Experience in 3D human tissue culture, biochemistry and pharmacology are strong merits. The candidate must hold a Bachelor’s degree in a relevant subject.
What do we offer?
A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is also a state university, which entitles you to several good benefits through our collective agreement. And you get to practice freely in our modern wellness facilities, where trained staff are on site.
Location: Campus Solna.
Read more about the lab here: Personalized Medicine and Drug Development – Lauschke-lab
Application
Welcome to apply at the latest 2025-01-03.
The application is to be submitted through the Varbi recruitment system.In this recruitment, you will apply with your CV without a personal letter. Instead, you will answer some questions about why you are applying for the job in the application form.
Want to make a difference? Join us and contribute to better health for all
