The Department of Immunology, Genetics and Pathology at Uppsala University has a broad research profile with strong research groups focused on, among other things, cancer, genetic and autoimmune diseases. One of the guiding principles at the department is to stimulate translational research and thereby promote closer collaboration between medical research and healthcare. Research is conducted within six research programs: cancer precision medicine, cancer immunotherapy, genomics and neurobiology, molecular tools and functional genomics, neuro-oncology and neurodegeneration, and vascular biology. Parts of the activities are also integrated with the departments of oncology, clinical genetics, clinical immunology, clinical pathology and hospital physics at the University Hospital. The department has teaching assignments in a number of program educations, independent courses and international master’s programs within the Faculty of Medicine and the Science and Technology discipline. The department has a turnover of around 550 million SEK, of which around two-thirds are external research grants. The number of employees is around 400, of which around 100 are doctoral students, and there are a total of over 850 active members of the workforce. Please read more about the department’s activities here: www.uu.se/medarbetare/institution/immunologi-genetik-och-patologi
Job duties
The project focuses on vascular permeability and implementation of a new treatment for excessive vascular permeability in eye disease. The tasks include the following:
– Injection of inhibitory substance into skin (so-called Miles assay) or eyes (intravitreal) in rodent models, followed by monitoring of leakage of circulating fluorescent substances to the tissue.
– Removal, fixation, and immunostaining of tissues followed by microscopy.
– Visualization of molecular interactions in tissues and cell culture, for example by so-called proximity ligation.
– Investigation of signal transduction in tissues by injection of agonists into the circulation, followed by extraction of blood vessel cells (endothelium) and biochemical analysis.
– Performance and participation in structural protein analyses through model ring programs or transmission electron microscopy.
– Genotyping and breeding planning of rodent strains.
– Compilation and statistical analysis of the results, orally and in writing.
– Some supervisory functions towards others active in the project, both within the own laboratory and external contractors.
Qualification requirements
– Good theoretical and practical insights and experience in methods for analyzing blood vessel function, especially with regard to blood vessel leakage.
– Excellent skills in statistical analysis methods.
– Very good knowledge in advanced confocal microscopy and electron microscopy.
– Initiative, excellent social skills and ability for critical thinking and troubleshooting.
– Good verbal and written communication in English.
About the employment
The employment is limited in time, 12 months. The scope is full-time. Entry date 2025-05-01. Location: Uppsala
Information about the position is provided by: Lena Claesson-Welsh, lena.welsh@igp.uu.se
Welcome with your application no later than February 28, 2025, UFV-PA 2025/173.
