About the position
A researcher SKO 1109 is to be employed in 100% position in the research group of prof. Harald Stenmark on the project “Simaphagy against cancer”, financed for 3 years by the Norwegian Cancer Society. Starting date 01.01.2025.
The project concerns studies of a new cellular mechanism, simaphagy, which entails degradation of organelles involved in signal transduction. The aim of the project is to understand the molecular mechanisms that regulate simaphagy, and to investigate the iimportance of stalled simaphagy in cancer development.
ob description and work tasks
The researcher will independently plan and carry out biochemical, molecular biological and cell biological experiments for studies of simaphagy. He/she will collaborate with experts in electron
microscopy and cancer biology. The work will be performed in the laboratories of Centre for Cancer Cell Reprogramming (CanCell), in the premises of Institute for Cancer Research, Montebello.
- Generate plasmid constructs for relevant proteins that regulate simaphagy
- Generate stable cell lines, including gene edited lines
- Prepare recombinant proteins for in vitro studies
- Analyse protein-protein and protein-membrane interactions in vitro
- Analyse cells and conditioned media by mass spectrometry
- Study cell lines by advanced light microscopy
Qualification requirements
- Doctoral degree in molecular cell biology
- Extensive laboratory experience in advanced molecular biology, including CRISPR technology
- Experience with intracellular trafficking and protein secretion
- Experience with preparation of recombinant proteins
- Experience with protein biochemistry, including proteomics and posttranslational
modifications - Extensive experience with biochemical analyses of proteins and their interactions with
membranes - Extensive experience with advanced light microscopy, including confocal microscopy and
microscopy of live specimens
Personal qualifications
- Ability to cooperate with others
- Ability to work independently
- Excellent oral and written communication skills
We offer
- Salary range of NOK 604 900 – 777 900 in position as Researcher, SKO 1109
- A good and safe working environment and participation in one of Norway´s best research
environments - Access to modern laboratories with advanced instrumentation
- Good social benefits
- Workout during working hours
- Good pension arrangements og beneficial loans in Statens Pensjonskasse
The application should include
• Application letter
• CV
• Diplomas, recommendations, list of 2-3 referees (name, association with applicant, e-mail address, and telephone number)
Application with attachments must be submitted via our recruitment system Jobbnorge.
Formal regulations
Please see the guidelines and regulations for appointments of researchers at the University of Oslo.
According to the Norwegian Freedom of Information Act (Offentleglova), information about the applicant may be included in the public applicant list, also in cases where the applicant has requested non-disclosure.
The University of Oslo has an agreement for all employees, aiming to secure rights to research results etc.
Inclusion and diversity are a strength. The University of Oslo has a personnel policy objective of achieving a balanced gender composition. Furthermore, we want employees with diverse professional expertise, life experience and perspectives.
If there are qualified applicants with disabilities, employment gaps or immigrant background, we will invite at least one applicant from each of these categories to an interview.
Contact information
For questions about the position:
- Professor Harald Stenmark, e-post: h.a.stenmark@medisin.uio.no
For questions about electronic application and procedure:
- HR senior consultant Anne Carine Wåsjø Kjuus, e-post: a.c.w.kjuus@medisin.uio.no
