About the position
Applicants are invited for a one-year position as Researcher in molecular medicine to be based at the Institute for Biosciences, Section for Biochemistry and Molecular Biology, University of Oslo. The successful candidate will physically work at the Norwegian Radium Hospital. The start date is April 2025.
Job description
In the NFR-funded Norwegian Center of Excellence ‘CanCell’ we are interested in developing new methods to reprogram cancer cells. One line of research involves participation in a Nordic phase II clinical trial. Here, Acute Myeloid Leukemia (AML) patients are treated with low-dose azacitidine/venetoclax, and an important aspect of this trial involves in-depth characterization of the effects of the therapeutic agents. To better understand how the cancer cells and immune system is affected, we are currently using a combination of ex vivo drug screening and multiparameter flow cytometry method to be able to identify the various types of immune cells and cancer cells that are present in bone marrow and peripheral blood of AML patients. Several other analyses will also be performed, such as expression analysis of selected genes by qPCR, and cytokine measurements.
The candidate will contribute to the project by developing routines for analysis of large datasets obtained with multiparameter flow cytometry (over 40 cell surface markers). In parallel, we will perform microbiome analysis of patient samples. The candidate will use these methods to analyze complex datasets obtained from multiple patients, and correlate this information with various patient characteristics to determine disease progression and outcome.
The work will be conducted in the Cancer Molecular Medicine group headed by Dr. Enserink, which is physically located at the Radium Hospital.
More about the position
The appointment is a fulltime position and is made for a period of one year. The main purpose of the fellowship is to qualify researchers for work in higher academic positions within their disciplines.
Qualification requirements:
The Faculty of Mathematics and Natural Sciences has a strategic ambition to be among Europe’s leading communities for research, education and innovation. Candidates for these fellowships will be selected in accordance with this, and expected to be in the upper segment of their class with respect to academic credentials
- Applicants must have completed a PhD degree equivalent to a Norwegian doctoral degree in Biology prior to the application deadline and have experience as a postdoctoral researcher in the field of research relevant for this position
- Fluent oral and written communication skills in English is essential
- The candidate must have experience with biobanking of patient samples
- It is essential that the candidate has proven experience with drug combination screening and analysis of the data by flow cytometry
- Experience with multiparameter flow cytometry and Incucyte fluorescence microscopy is essential
- Proven experience with methods commonly used in molecular cell biology, such as antibody staining, analysis of cell viability, CRISPR/Cas9 modification of cell lines
- Proven experience with RT-qPCR and RNAseq
The following qualifications will count in the assessment of the applicants:
Personal skills:
We are looking for a talented, enthusiastic and determined person. The successful candidate is highly self-motivated and can work highly independently, but also constructively in the context of a dynamic team. The work will be conducted in tight collaboration with a strongly interconnected interdisciplinary team, which requires effective communication and good personal skills. The candidate has adaptive skills, has a strong work ethic and is focused on delivering high-quality data. The successful candidate is positive-minded and is well organized in terms of planning experiments and documenting research results.
Personal suitability for the position will be emphasized.
We offer:
- Salary NOK 575 400 – 700 000 per annum depending on qualifications in position as Researcher (position code 1109)
- A professionally stimulating working environment
- Attractive welfare benefits and a generous pension agreement, in addition to Oslo’s family-friendly environment with its rich opportunities for culture and outdoor activities
The application must include:
- Cover letter (statement of motivation, summarizing scientific work and research interest)
- Project description for conducting this project, including progress plan
- CV summarizing education, an overview of all previous and current positions including administrative experience
- A description of qualifying activities that support the Qualification Requirements for this position
- Copy of PhD certificate
- A complete list of publications
- List of reference persons: 2-3 references (name, relation to candidate, e-mail and phone number)
The application with attachments must be delivered in our electronic recruiting system, please follow the link “apply for this job”. Foreign applicants are advised to attach an explanation of their University’s grading system. Please note that all documents should be in English (or a Scandinavian language).
In assessing the applications, special emphasis will be placed on the documented, academic qualifications, the project description, and the quality of the project as well as the candidate’s motivation and personal suitability. Interviews with the best qualified candidates will be arranged.
It is expected that the successful candidate will be able to complete the project in the course of the period of employment.
Formal regulations:
According to the Norwegian Freedom and Information Act (Offentleglova) information about the applicant may be included in the public applicant list, also in cases where the applicant has requested non-disclosure.
The University of Oslo has an agreement for all employees, aiming to secure rights to research results a.o.
The University of Oslo aims to achieve a balanced gender composition in the workforce and to recruit people with ethnic minority backgrounds.
Contact persons:
For further information about the position please contact Prof. Jorrit Enserink, phone: +47 23074066, e-mail: jorrit.enserink@ibv.uio.no.
For technical questions regarding the recruitment system please contact: HR-adviser Nina Holtan, phone: +47 22854424, e-mail: nina.holtan@mn.uio.no.
