PhD Bespoke Organometallic Compounds for Anticancer Studies
PhD @Loughborough University posted 7 hours agoJob Description
Project details
Organometallic compounds, complexes bearing a M-C bond, constitute a highly important class that find uses in a multitude of areas. Various globally significant applications, for example, developing new drugs for medicinal chemistry can attribute their huge success to the diversity of ancillary ligands that can be incorporated to access libraries of organometallic compounds possessing similar structural features.
We have been interested, for many years, in studying the chemistry of various organometallic compounds based primarily on late transition metals such as ruthenium, rhodium, iridium, palladium, and platinum to name but a few. Ideal spectator ligands, complimentary to those aforementioned target metals, often include specific Group 15 donor atoms incorporating nitrogen or phosphorus centres that can firmly anchor these metal centres.
In this exciting project, we will use synthetic methodologies developed in our research group to prepare novel families of (i) New fluorescent Schiff base chelating ligands and (ii) Preorganised fluorescent diphosphane ligands with unique bridging capabilities for anchoring two organometallic metal centres. Once synthesised and characterised, these compounds will be systematically evaluated for their cytotoxic properties.
This project will provide an excellent training opportunity, for a prospective PhD candidate, in modern well-equipped laboratories with access to multinuclear NMR facilities, X-ray crystallography, fluorescence spectroscopy, elemental imaging and bio lab testing facilities.
94% of Loughborough’s research impact is rated world-leading or internationally excellent. REF 2021
Supervisors
Primary supervisor:Â Dr Martin Smith
Secondary supervisor:Â Dr Amy Managh
Entry requirements
Our entry requirements are listed using standard UK undergraduate degree classifications i.e. first-class honours, upper second-class honours and lower second-class honours. To learn the equivalent for your country, please choose it from the drop-down below.
Entry requirements for United Kingdom
Applicants should have or expect to achieve at least a 2:1 honours degree (or equivalent international qualification) in chemistry.
English language requirements
Applicants must meet the minimum English language requirements. Further details are available on the International website.
Fees and funding
Tuition fees for 2024-25 entry
UK fee
£4,786 Full-time degree per annum
International fee
£27,500 Full-time degree per annum
Fees for the 2024-25 academic year apply to projects starting in October 2024, January 2025, April 2025 and July 2025.
Tuition fees cover the cost of your teaching, assessment and operating University facilities such as the library, IT equipment and other support services. University fees and charges can be paid in advance and there are several methods of payment, including online payments and payment by instalment. Fees are reviewed annually and are likely to increase to take into account inflationary pressures.
How to apply
All applications should be made online. Under programme name, select *the school/department name*. Please quote the advertised reference number: CM/MS-SF1/2025 in your application.
To avoid delays in processing your application, please ensure that you submit the minimum supporting documents.
The following selection criteria will be used by academic schools to help them make a decision on your application.
