Job Description
Lab Overview
My research program to date has contributed to our fundamental understanding of how changes in ‘receptor structure leads to function’. Using specialized quantitative imaging techniques with complementary cell and molecular biology approaches both in vitro and in vivo, I have uncovered novel ways by which the cytokine receptor, Growth Hormone Receptor (GHR), regulates several biological functions in normal physiology and cellular dysfunction. GHR is expressed in every physiological system of the body and any aberrant signaling owing to internal factors (genetic) or external factors (environment) or both can result in cellular dysfunction. I deciphered the mechanism of the first single nucleotide polymorphism of GHR associated with increased susceptibility to lung cancer. Concurrently, my work described the mechanism of anti-insulin effects of Growth Hormone, a phenomenon that has remained elusive for 50 years. Using innovative mouse models with delineated GHR signaling I showed impaired gluconeogenesis and glucose metabolism via GH-mediated JAK2/STAT5 action. A critical attribute of calorie restriction or intermittent fasting is reduction of GH and improvement of insulin sensitivity which is where my research fills the gap. Subsequent to my PhD in GHR biology, my postdoctoral research has shed light on the effect of single nucleotide polymorphisms in pigmentation genes (IRF4, MTAP and PLA2G6) on melanocytic biology as well as the role of MITF and BRN2 transcription factors in ‘melanoma phenotype switching’ and role of orphan nuclear receptor NR4As in DNA repair.
In the Weeraratna Laboratory, I undertook how sex as well as the age of the host microenvironment guides metastasis, dormancy, and therapy resistance in melanoma. Using a unique resource of normal skin fibroblasts from healthy donors stratified by age across both the sexes and utilizing animal models, my research program aims to determine the metabolic, biophysical, and biochemical changes that affect the communication between tumor, stromal and immune cells thereby regulating metastasis and therapeutic responses. The implications of these data will ultimately result in change in the current clinical practice. My long-term research goal as an independent investigator is in precision oncology by taking a holistic approach and incorporating gender medicine and geroscience.
Educational Background
- 2014 Doctor of Philosophy (Summa Cum Laude) Biochemistry and Cell Biology The University of Queensland, Australia
- 2009 Masters in Science (GPA: 7.0/7.0) Biotechnology The University of Queensland, Australia
- 2007 Bachelor of Technology (Score: 89.11% High Distinction) Biotechnology Sathyabama Deemed University, Chennai, India
Open Positions
About the Position
The laboratory of Dr. Yash Chhabra at the Fox Chase Cancer Center in Philadelphia, PA, USA, is seeking skilled and self-motivated Postdoctoral Associate in Cancer Biology to join our efforts to understand the complex molecular mechanisms underpinning age and sex disparity in non-reproductive solid cancers both at the systemic and tumor microenvironment level. We use multi-disciplinary OMICS approaches to study how the host-factors create a tumor-permissive niche and regulate therapeutic responses and develop resistance by integrating signaling transduction, biochemistry, cell and molecular biology and immunology with mouse models and patient samples. The Chhabra lab collaborates with investigators from both within Fox Chase and Temple Health. The successful candidate will be part of an inclusive, dynamic, and stimulating academic environment with opportunities for professional development in four core areas of scientific communication, leadership, teaching, and mentorship.
Qualifications
- The candidate should have a PhD (or equivalent) degree or be close to obtaining their doctoral degree in cancer biology, cell and molecular biology, or a related field. A strong background and familiarity in tumor microenvironment, metastasis and immunology concepts is desirable.
- The candidate should possess documented experience as publications in basic cellular and molecular biology techniques. Experience with handling and experimentation on mouse models is highly desirable.
- The candidate is expected to be motivated, organized, and capable of working independently and in a team environment.
- The candidate should be proficient in analyzing and interpreting results, review and present data for publications and presentations and engage in departmental seminar and activities.
About the Training Environment
As one of the four original cancer centers to receive comprehensive designation from the National Cancer Institute, Fox Chase Cancer Center has been at the forefront of cancer research for almost 90 years. We are home to excellent research facilities, top clinicians and scientists, and outstanding patient care. Our singular focus on cancer, which couples discovery science with state of the art clinical care and population health, remains the foundation of our work.
The scientist training programs at Fox Chase Cancer Center provide professional development opportunities in four core areas identified as crucial for successful careers in science, research, and health care including communication, leadership, teaching, and mentorship. Upon joining the program, graduate students and postdocs develop individual development plans to help guide their growth. Training throughout the year is supplemented with free professional development opportunities, including a robust ‘How To’ series, writing courses, networking, mentorship, and teaching opportunities, a trainee-led seminar series, a trainee-led annual Research Conference, and more. Postdocs at Fox Chase Cancer Center are supported by the Temple University Postdoc Association and the Office of Academic Affairs at Fox Chase, and are compensated with competitive pay and benefits.
In addition to the robust training program, scientists at Fox Chase Cancer Center benefit from being part of the rich scientific and biotech environment in the Philadelphia region. Many of our former trainees are now employees (and contacts) at nearby institutions and companies, including The Wistar Institute, Merck, GSK, AACR, and numerous others.
To Apply
If you are interested in joining the laboratory, please submit a cover letter describing your motivation in pursuing this postdoctoral position and research interests and accomplishments, copy of your current CV, and a list of three references directly to:
Yash Chhabra, PhD
Assistant Professor,
Fox Chase Cancer Center
Yash.Chhabra@FCCC.edu
Short-listed candidates will be invited for a preliminary zoom interview.
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