Postdoctoral Researcher Positions – Neurodegeneration & Cancer Biology
Postdoc @University of Pennsylvania posted 1 week agoJob Description
The laboratory of Professor Xiaolu Yang is seeking two highly motivated postdoctoral researchers to join our dynamic team. We investigate fundamental mechanisms underlying neurodegenerative diseases and cancer, with current projects centered on the following two areas:
- Protein Quality Control, aging, and Neurodegenerative Diseases
We have discovered two novel protein quality control (PQC) systems involving tripartite motif (TRIM) proteins and poly-Asp/Glu (polyD/E) proteins. These systems are ATP-independent and uniquely conserved—TRIM in animals and polyD/E in eukaryotes—setting them apart from classical PQC mechanisms. We are exploring their molecular mechanisms, their roles in aging and neurodegenerative diseases (including Alzheimer’s, Parkinson’s, and ALS), and their potential in therapeutic development.
- Tumor Suppression, Metabolism, and Autophagy
We study the regulation and function of the tumor suppressor p53, focusing on its roles in metabolic pathways essential for biosynthesis and redox balance. Our work explores how p53 functions as both a sensor and regulator of cellular metabolism. We are also identifying metabolic alterations that contribute to tumor initiation and progression. A recent extension of this work examines the role of metabolism and autophagy in stem cells, including embryonic and cancer stem cells.
For more information about our research, please see the following publications and website:
Science 381: eadd6696 (2023), PMID: 37499037
Science Advances 8: eabo0404 (2022), PMID: 35857842
Nature 597: 132-137 (2021), PMID: 34408321
Nature Cell Biology 23: 978–991 (2021), PMID: 34497368
Cell Metabolism 33: 94-109 (2021), PMID: 33159852
Science 369: 397-403 (2020), PMID: 32703873
Cell Reports 33: 108418 (2020), PMID: 33264628
Nature Communications 11: 348 (2020), PMID: 31953436
Nature Communications 10: 1495 (2019), PMID: 30940803
Cancer Research 79: 2220-2231 (2019), PMID: 30890618
Nature Communications 9: 4683 (2018), PMID: 30409970
Nature Communications 9: 1223 (2018), PMID: 29581427
Cell Reports 18: 3143-3154 (2017), PMID: 28355566
Molecular Cell 55: 15-30 (2014), PMID: 24882209
Nature 493: 689-93 (2013), PMID: 23334421
Nature Cell Biology 15: 991-1000 (2013), PMID: 23811687
Proc Natl Acad Sci U S A 108: 12851-6 (2011), PMID: 21768358
Nature Cell Biology 13: 310-316 (2011), PMID: 21336310
Molecular Cell 37: 668-678 (2010), PMID: 20227371
https://www.med.upenn.edu/apps/faculty/index.php/g275/p20138
Application Instructions
To apply, please send a cover letter, curriculum vitae, and contact information for three references to Xiaolu Yang, PhD, email: xyang@pennmedicine.upenn.edu
Qualifications
Applicants should have a strong publication record and relevant experience in areas such as molecular biology, biochemistry, cell biology, neuroscience, cancer biology, metabolism, stem cell biology, and/or animal models.
Contact To apply, please send a cover letter, curriculum vitae, and the names and addresses of three references to:
Xiaolu Yang, PhD
Professor, Department of Cancer Biology
Investigator, Abramson Family Cancer Research Institute
Perelman School of Medicine
University of Pennsylvania
653 BRB 2/3, 421 Curie Blvd
Philadelphia, PA 19104-6160
Email: xyang@pennmedicine.upenn.edu
