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(1) Cover Letter Template

Dear Dr. XXX,

I am a graduate student in the laboratory of Dr. xxxx at xxxx University, India (Ph.D. Awarded). This letter is in reference to any postdoc position available in your lab. Having been familiar with your research and recent publications, I’m interested in joining your lab, with particular interest in the area of epigenetic modifications of tumor suppressive non-coding RNAs and cancer manifestation. I believe that your laboratory offers the perfect opportunity for me to apply all that I have learned in graduate school and further my scientific endeavor.

My graduate research was focused on ameliorating potential of thymoquinone against the toxic effects of iron oxide nanoparticles both in vitro (primary splenocytes) and in vivo model system (albino rats). Superparamagnetic iron oxide nanoparticles (SPIONs) offer a broad spectrum of application in the various field of biomedical sciences including magnetic resonance imaging (MRI), drug delivery, cell labeling, hyperthermia etc. (xxx et al., xxx. 2020). SPIONs are known to induce cytotoxicity in various cancer cell lines through the generation of reactive oxygen species (ROS). However, the studies on its potential to induce toxicity in normal cell lines and in vivo system are limited and ambiguity still exists. Additionally, small molecules are known to interact with the DNA and cause damage to the DNA (xxx et al., 2019). We found that thymoquinone (natural antioxidants) have potential to ameliorate the cytotoxic and genotoxic effects induced by SPIONs both in vitro and in vivo (xxx et al., xx 2020). I am familiar to various techniques such as cell culture, cell viability assays, ROS estimations, ELISA, gene amplification (PCR), gene manipulation, microbial culture, chromosomal aberration assay, micronucleus test, single cell gel electrophoresis (comet assay), UV-Vis spectroscopy, Spectrofluorometry, histopathology, animal handling etc. Now, I’m keen to learn and embrace additional techniques being used in your lab and whatever new will be required to execute research plans.

Since my graduate schooling, I am always very interested in epigenetic phenomenon, specially related to cancer and its progression. What I can understand from your work and that of others are that epigenetic factors play an important role in tumorigenesis. Since its very well known that many oncogenic miRNAs contributes to cancer development, my interest is to identify that factors contributing to epigenomic modifications during oncogenesis. For instance, mutations in chromatin modifiers and its relation to cancer related process. The other aspects that I would like to address is genomic loss of genes via karyotyping (band analysis), for instance, epigenome related to tumor suppressive miRNAs as well as its chemical modifications (methylation). The gene and drug delivery using ligand conjugated nanoparticles will also be one of my priorities. Given an opportunity, I would like to work in your laboratory with my full efforts and technical expertise. However, I’m open to shape and adapt the research plan according to your precise vision and scientific goals. I’m hopeful that you will extend your guidance to me. I can prepare a more focused and concise plan of work after getting your consent and current research work going on in your lab. Please find enclosed my curriculum vitae for your review and let me know if you have any query.

Thank you for your time and consideration.

I look forward for your response.

With kind regards

Sincerely yours

xxx

(2) Cover Letter Template

Dear Dr..,

This is regarding to my interest for the Postdoctoral position in your laboratory. My background is biotechnology with extensive experience in plant metabolite production, cell biology, cell culture, protein expression, purification and characterization, bioinformatics tool docking and simulation.

Currently, I have completed my PhD in November 2020 under supervision of Prof xxx, Department of Bioengineering, xxx University. My PhD research is based on “Study of anticancer potential of xxx sprout and its nanoformulation on liver carcinoma cell line, since Dec xx.

During Ph.D, I worked as a JRF in the project entitled “In vitro and in vivo study of hepatoprotective activity of xxx extracts in various germination stages”. In the study, the mechanism of the cytotoxicity of N. sativa and its sprouts on liver cancer cell line using in silico, in vitro and in vivo approaches was elaborated. The work has been published in high quality journals in herbal drug/ plant drug analysis.

I have working experience in few formulations for skin cancer and liver cancer performed short term animal study with Swiss albino mice model and analysed the skin tissue sample for western blotting and PCR at protein and mRNA level and also done the project on expression, purification and characterization of protein using Pichia pastoris as an expression system. And I have some working experience on technique like HPLC, LC-MS, biological activities such as extraction and purification of secondary metabolites from plant extract, establishment and maintenance of animal tissue culture laboratory, handling & culturing mammalian cell lines, media preparation for mammalian cell lines, DNA & RNA isolation, PCR,qRT PCR, fluorescence microscopy, cell viability analysis, cytotoxic analysis, genotoxic analysis, reactive species generation monitoring, TLC, SDS-PAGE and Agarose Gel Electrophoresis and bioinformatics.

I am highly interested in exploring the bioactive natural product and therapeutic intervention thereafter. I have experience in preparation of different nanoformulation from plant extract apart from other in vitro and in silico studies. Further, I am prone to learn new techniques and implement them precisely in my studies. Please find my other credentials and references in the resume attached herewith. If you require any further information I shall be happy to furnish the same. Hope, I will be a significant addition to your lab.

Sincerely,

Dr. xxx

Integral xxxx

(3) Cover Letter Template

Dear Prof. xxxx

I, Dr. xxxx, wish to express my interest for a postdoctoral position available in your esteemed laboratory. I am highly motivated by your research theme and feel great pleasure to write you about the possible opportunity. In December 2016, I have been awarded with Ph.D. degree in Science on the topic entitled “xxxxxx of Metals and Carbon-based Nanomaterials (CNMs) induced toxicity” from xxx.

During my doctoral research, I get acquainted with nitty-gritty of nanoscience and nano-bio interface, particularly the synthesis and interaction of cerium and carbon family nanomaterials (carbon nanotubes, graphene oxide and graphite carbon nanofibers) with human lung cells as well as Swiss albino mice lungs. We explored that cerium oxide, carbon nanotubes and graphene oxide causes cell death in lung cells (cancer and normal) via oxidative stress induced apoptosis and necroptosis. These cell death pathways were closely associated with the unique physicochemical properties of NM and cellular phenotypes (xxxx et. al., one manuscript under preparation). Moreover, graphite carbon nanofibers induced cell death in human lung cells was assessed which describes the underlying role of autophagy-apoptosis-oxidative stress axis (xxx et al., revision submitted in xxx). Furthermore, the adverse effect associated with the in vivo exposure of CNM in mice lungs was explored which showed the role of frustrated phagocytosis, fibrosis and TGF β/Smad pathway underlying the toxicity of CNM (Manuscripts under review/preparation).

My doctoral research has provided me the opportunity to gain experience in in-vivo and in-vitro experimentation, genotoxicity, biochemical and molecular biology techniques, Flow-cytometry, animal handling and exposure, cell signaling, independent planning and execution of experiments and data analysis.

I am highly motivated and independent research scholar having a strong interest in the field of nano – biointerface particularly the interaction of nanomaterials with proteins and their implication in nanomedicine and targeted drug delivery. Presently, we are studying the anti-cancer effect of graphene oxide – chloroquine nanoconjugate in human lung cells. We identified the role of impaired autophagic flux mediated necroptosis and trying to understand the underlying molecular mechanism. Also, we are working on to assess the combinatorial effect of Gold-Zinc nanoparticles with X-ray to improve the anti-cancer potential of current radiotherapy techniques.

It would be a great pleasure for me to be a part of your lab. Provided an opportunity, I firmly believe that with my research experience and skills, I can significantly contribute to the ongoing research themes in your lab. Kindly find enclosed my CV including list of publications and referee details for your kind consideration. I will feel happy to provide any other information, if required.

Thanking you for your time and kind consideration. I look forward for a positive reply from your end.

xxxxx

(4) Cover Letter Template

Dear Dr. xxxx,

I am writing this letter to express my interest for the “Postdoctoral Research Opportunity floated by your group in the field of Theoretical/computational biophysics, computational biology/ medicine, molecular & structural biology. I find the floated job profile is very much similar to my research interest and I strongly feel that I could be one of the potential candidate for this job and possibly I can prove my suitability if I get chance.

In my Postdoctoral research I am working on Membrane simulations specific to understanding the “Membrane disruption Mechanism of Antimicrobial Peptides. In my 1.5 year postdoctoral experienced I have already published two papers and we are working on 3 more manuscripts that can be possibly get published before the end of this year. The membrane protein simulation specifically understanding the membrane disruption mechanism of Antimicrobial peptides (AMP) are longer time scale biological events. We have generated about 200 μs cumulative all atoms MD trajectory for several AMP. We have observed several spontaneous events that are new for scientific community and preparing our manuscripts for targeting high impact journals. My postdoctoral group is well known for publishing high impact papers in this field that can be seen by visiting our group web. I would be happy to discuss my research in details if I get opportunity. In PhD, I get experienced in computational Biophysics specific to “Molecular Modeling and Simulation of Proteins and Peptides. I worked on certain protein and peptides to explore the role of Dynamics in protein/peptides function and applications like drug design (See the publications for details).

Recently, I have submitted a proposal entitled “Understanding the Mechanism of Aggregation and Non-gated Ion-channel Formation of Aβ-Peptides on/in Membrane models: A Molecular Dynamics Simulation Study” to DST INDIA, and this proposal is on final stage of selection. Thus, I have already been very much aware about the recent literatures on Aβ-Peptides. I am sending my project summary with this covering letter for your consideration and I would be happy to discuss in details if you like.

With my expertise and experience in Science I firmly believe that I am a potential candidate for this position. Please see my resume for additional information.

Thank you for your time and consideration. I look forward to speaking with you about this employment opportunity.

Sincerely yours,

xxxx

(5) Cover Letter Template

 Dear Professor xxxx,

I am writing this letter in pursuance of availability of a Postdoctoral Fellow position in your laboratory. I earned my PhD degree in Biotechnology and Bioinformatics in 2014 from the University of Hyderabad, India. Subsequently, I pursued as postdoctoral research fellow (May 2015- April 2018) in the Laboratory of System Biology of Cancer at the Department of Molecular Biology and Genetics, xxxx.

My PhD research work mainly concerned with the implementation of various in silico and in vitro approaches to understand the regulatory roles of microbial oncogenes in the context of chronic inflammation, apoptosis and cancer. During this period, I had extensively contributed towards standardizing the methods for bacterial gene cloning, protein expression, purification and characterization, flow cytometry analysis and cell-based immune signaling. My recent research experience as postdoctoral scientist at xxxx University relates with system level analysis of mechanisms of therapy resistance and metastatic progression in breast cancer models. I therefore gained expertise in using the computational approaches (RNA-seq and proteomics) and clinical data analysis to identify novel druggable targets (both coding and non-coding RNA drivers) for cancer prevention. Moreover, I have gained exposure in applying the cytobiology, biochemistry and functional genomics tools in in vitro and in vivo settings. Of particular interest, I have also been experienced in siRNAs, shRNAs and sgRNAs/ CRISPR/ Cas9 based screening of targets genes/factors in primary and resistant cancer cell line models, 3D culture and xenograft mouse tumor models for in depth understanding of signaling mechanisms involved in therapy-resistant cancer development. In this context, my current focus of research is to explore the transcription/ post-transcriptional regulatory activities of mediator complex proteins (CDK8-module) in development of hormonal-therapy resistance in ER+ breast cancer. I am confident that my research and technical backgrounds will greatly help me in impactful accomplishment of the project in your lab.

As you can see in my curriculum vitae (CV) that I have authored 8 scientific papers in peer-reviewed international journals and currently two articles are in the process of submissions (including my recent research work as first author). Besides, participation in a number of national and international level scientific programs enabled me to develop strong communication and problem solving skills.

I would highly appreciate you for considering my application. Please also find attached copy of my CV which provides more details of my experiences, research and skills to meet the requirement of this position. Please feel free to contact me to further explore my suitability.

Sincerely,

Dr. xxx

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