The Caleigh Mandel-Brehm lab in the Pathology Department at Yale has an opening for a postdoctoral fellow with interests in the fast-emerging field of neuroimmunology. There is increased recognition that immunopathology is directly involved in diseases affecting the brain, but the mechanisms causal to breech of the protective blood brain barrier, and subsequent cytotoxicity targeted to different brain regions, remain poorly understood.
Driving new breakthroughs in understanding these mechanisms has been the development of new technologies during my postgraduate research at UCSF, such as new adaptations of a phage sequencing approach, leading to discovery of novel brain antigen targets in a class of autoimmune paraneoplastic neurological syndromes. Now, this and other emerging technologies, such as combining use of human brain tissue and mouse models, are being applied in my lab at Yale. As such, my lab offers an ideal platform for discovery and career training.
Qualified applicants will participate in ongoing projects based on their interest and building on their previous predoctoral training. The proposed project will involve training in human iPSC-derived neural cells and utilize wide ranging molecular technologies including mass spectrometry, single-cell RNA analysis, and imaging. The ideal candidate will also spearhead a new approach for studying the latent autoreactome in postmortem human brain tissue.
As part of mentorship, I am fully committed to providing individual and team involvement in experimental design and execution, data analysis, presentations of your work and scientific writing. My lab has collaborations within the department at Yale, including a one-of-a-kind relationship with the Neuropathology Department and Brain Discovery Group, as well as with labs abroad.
Qualifications:
Candidates must have a strong research track record and hold a PhD or equivalent in biological sciences. Preferred training includes the areas of molecular biology (RNA/DNA and protein), immunology, cancer and neuroscience.
Compensation:
This position offers a competitive salary of $68,000/year, full healthcare benefits, and funding to attend conferences. Yale provides a vibrant postdoctoral community with resources to support family life, career development, and well-being. For information on postdoc salary, housing, the perks of living in New Haven, and more information please visit Yale office for postdoc affairs (https://postdocs.yale.edu/)
Apply:
Interested candidates please email me at Caleigh.Mandel-Brehm@yale.edu with a cover letter that describes their general interests, prior training and career goals, well as a CV with 3 references. Interviews will be conducted in-person or zoom depending on geographic constraints.
